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Journal of the Mexican Chemical Society

Print version ISSN 1870-249X


POGGI, Mariana et al. New Isoniazid Complexes, Promising Agents Against Mycobacterium tuberculosis. J. Mex. Chem. Soc [online]. 2013, vol.57, n.3, pp.198-204. ISSN 1870-249X.

Tuberculosis (TB) is a public health disease that produces several million deaths annually worldwide. Due to this critical situation and the appearance of drug-resistant microbial strains, innovation in TB drug discovery is a research priority. In this work, the synthesis and characterization by elemental analysis, thermogravimetry, conductimetric measurements and spectroscopies UV-Vis, IR and EPR of [Cu(INH)(H2O)]SO4 ⋅2H2O (Cu-INH) and [CoCl(INH)2(H2O)] Cl⋅2.5H2O (Co-INH) complexes with isoniazid (INH) are reported. Besides, the lipophilicity, the activity against Mycobacterium tuberculosis (MICCu-INH = 0.78 µg/mL and MICCo-INH = 0.19 µg/mL) and the cytotoxicity (IC50 = 48.8 and 625 µg/mL for the copper and cobalt complexes, respectively) were measured and the selectivity index (62.5 for Cu-INH and 3205 for Co-INH) was calculated. These results indicate that these complexes are good candidates for further studies.

Keywords : copper and cobalt complexes; isoniazid; antimycobacteria activity; tuberculosis; spectroscopy.

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