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Journal of the Mexican Chemical Society

Print version ISSN 1870-249X


VARA-GAMA, Nancy et al. Physicochemical and Biopharmaceutical Evaluation of Casiopeina III-Ea, a New Compound with Antineoplastic Activity. J. Mex. Chem. Soc [online]. 2021, vol.65, n.3, pp.308-317.  Epub Feb 14, 2022. ISSN 1870-249X.

In the present work, the physicochemical (pka, intrinsic solubility, Log D distribution coefficient) and biopharmaceutical characterization (IC50 studies in MDCK cells) of Casiopeina III-Ea, a Cu (II) mixed chelate compound, was carried out. These parameters will tell us about the behaviour of Casiopeina III -Ea, as a new antineoplastic agent, in physiological media. This basic research of the Faculty of Chemistry of the UNAM, is directed towards the maturation of a technology, which consists of the pharmaceutical development of an antineoplastic copper coordination compound Casiopeina III-Ea.

Keywords : Casiopeina III-Ea; physicochemical properties; IC50; MDCK cells; copper.

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