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Journal of the Mexican Chemical Society

Print version ISSN 1870-249X

J. Mex. Chem. Soc vol.49 n.2 México  2005

 

Short Report

 

A Concise Total Synthesis of (R)-Fluoxetine, a Potent and Selective Serotonin Reuptake Inhibitor

 

Ângelo de Fátima, Alexandre Augusto M. Lapis and Ronaldo A. Pilli*

 

Instituto de Química, Universidade Estadual de Campinas, CP 6154, 13084-971, Campinas - SP, Brazil. * e-mail: pilli@iqm.unicamp.br

 

Received: November 6, 2004
Published on the web: April 12, 2005

 

Abstract

(R)-Fluoxetine, potent and selective serotonin reuptake inhibitor, has been synthesized in six steps, 50% overall yield and 99% ee from benzaldehyde via catalytic asymmetric allylation with Maruoka's catalyst.

Keywords: fluoxetine, serotonin reuptake inhibitor, catalytic asymmetric allylation

 

Resumo

(R)-Fluoxetina, um inibidor potente e seletivo da recaptação da serotonina, foi sintetizada em seis etapas, 50% de rendimento total e 99% de excesso enantiomérico a partir do benzaldeído via alilação catalítica assimétrica empregando-se o sistema catalítico desenvolvido por Maruoka e colaboradores.

 

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