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Revista odontológica mexicana
Print version ISSN 1870-199X
Rev. Odont. Mex vol.10 n.2 Ciudad de México Jun. 2006
https://doi.org/10.22201/fo.1870199xp.2006.10.2.15904
Trabajos originales
Asociación entre la periodontitis crónica y la respuesta inmunológica TH2
Association between chronic periodontitis and the immunologic TH2 response
* Departamento de Inmunología de la Escuela Nacional de Ciencias Biológicas del Instituto Politécnico Nacional. Becario PIFI. México.
§ Departamento de Inmunología de la Escuela Nacional de Ciencias Biológicas del Instituto Politécnico Nacional. México.
II Especialización en Endoperiodontología. FES Iztacala. UNAM. México.
La enfermedad periodontal afecta una gran parte de la población mundial. Dicha enfermedad es resultado de la interacción del hospedero con los microorganismos de la biopelícula, por lo cual, el tipo de respuesta inmunológica que prevalezca determinará el grado de la enfermedad. Se determinó el balance TH1/TH2 por la determinación inmunohistoquímica de interferón gamma e interleucina-13 en cortes histológicos de biopsias de encía de sujetos diagnosticados clínicamente e histológicamente, encontrando un predominio de la respuesta Th1 en salud, que se va perdiendo, con equilibrio Th1/Th2 en gingivitis y finalmente, un predominio Th2 en la periodontitis.
Palabras clave: Enfermedad periodontal; Th1; Th2
The periodontal disease affects a great part of the world’s population. This disease is a result of the interaction of the host with the microorganisms in the biofilm; therefore the type of immunological reaction will determine the grade of the disease. The Th1/Th2 balance, was determined by immunohistochemistry (using interferon gamma and interleukin-13) in histological sections of biopsies of the gum of patients previously diagnosed clinical and histologically. The result was a prevalence of Th1 in health and a balance Th1/Th2 in gingivitis with a trend toward Th2 in periodontitis.
Key words: Periodontal disease; Th1; Th2
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