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TIP. Revista especializada en ciencias químico-biológicas
Print version ISSN 1405-888X
TIP vol.9 n.2 Ciudad de México Dec. 2006
Artículos de revisión
Mecanismos moleculares que controlan el desarrollo de la extremidad de los vertebrados
Molecular mechanisms that controls vertebrate limb development
1Depto. de Biología Celular y Fisiología, Instituto de Investigaciones Biomédicas, UNAM. С.U., Apdo. Postal 70228, СР. 04510, México, D.F.
¿Cómo un grupo de células indiferenciadas pueden formar estructuras y tejidos altamente organizados y diferenciados?, ¿Cuál es la naturaleza de las señales que dictan estos eventos? ¿Cómo son los procesos del desarrollo que actúan para que las diferentes especies desarrollen estructuras similares pero adaptadas al medio en el que viven?
Uno de los modelos que han permitido responder en parte a estas interrogantes es la extremidad embrionaria. A partir de los estudios en la extremidad embrionaria se han propuesto una serie de interesantes paradigmas que han cambiado la percepción de ver a los procesos del desarrollo como aislados y poco dinámicos. En esta revisión, destacamos aquellos estudios que han contribuido de manera amplia a entender la inducción de la formación de la extremidad y el establecimiento de los centros organizadores que controlan su morfogénesis, así como el patrón esquelético que incluye la diferenciación del cartílago y la muerte celular.
Palabras Clave: AER; condrogénesis; extremidad embrionaria; identidad de los dedos; identidad de la extremidad; muerte celular programada; zona de progreso; ZPA
How can a group of undifferentiated cells develop into complex structures and highly organized and differentiated tissues? What is the nature of the signals that dictate these events? Which developmental processes act so that different species can develop similar structures adapted to the environment where they live? A model that partly answers these questions is the embryonic limb. Limb bud studies have suggested interesting paradigms that have changed the perception of development as an isolated and not very dynamic process. The present work reviews the studies that have led to understand the induction of the limb bud and the establishment of the organizing centers that control limb morphogenesis, as well as the skeletal pattern that includes cartilage differentiation and cell death.
Key Words: AER; chondrogenesis; limb bud; digit identity; limb identity; programmed cell death; progress zone; ZPA
Agradecimientos
Los autores quieren agradecer a todos los miembros del laboratorio por sus valiosos comentarios a este trabajo. El presente trabajo recibió apoyo financiero por parte del CONACYT proyecto 42568Q y por parte de DGAPA, UNAM proyecto IN200205.
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Recibido: 07 de Noviembre de 2006; Aprobado: 29 de Noviembre de 2006
Este es un artículo publicado en acceso abierto bajo una licencia Creative Commons
