Dear editor: Health measures to protect against Covid-19 are the main tool to curb infections,¹ yet misinformation and different cultural perceptions could be one obstacle towards this aim. This is especially the case of marginalized areas, especially indigenous populations.² After applying an extensive survey (N= 1 000) among young people (15-18 years old) from marginalized areas of the Southeastern state of Chiapas, we found that a large part of the study population: believed in the existence of the disease, knows the main symptoms and some contagion mechanisms (table I). Moreover, they also believed that the disease had a conspiratorial origin which may explain why they showed low care in sanitary measures against contagion. For example, a substantial number of respondents (48%) wore masks, engaged in social distancing (60%) or avoided attending meetings (65%). Furthermore, 43% of the study population felt highly threatened by the Covid-19 pandemic and feared for their local economy (37.19%). Related to the later, the most frequent feelings detected were fear (68%) and worrying (48%). These public actions and perceptions of the pandemic can help us understand the underlying factors in community decision-making for health care. We believe that there are two major challenges facing this pandemic in marginalized and rural areas: 1) the population’s mistrust of the authorities and 2) misinformation and the prevalence of false ideas that can undermine efforts to adopt preventive measures.³ Although changing the behavior of a society is difficult, creating motivational strategies and tools can render a positive impact. Given this, young people can play a strategic role in the response to mitigate the effects of Covid-19 by being in contact with scientific knowledge and their close relationship with new digital sources and social networks (Facebook, WhatsApp, Instagram, among others) that can serve as dissemination platforms.