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Revista mexicana de oftalmología
On-line version ISSN 2604-1227Print version ISSN 0187-4519
Abstract
BUESO-PONCE, Diego et al. Findings by SS-OCT and OCT-A in patients with sickle cell disease compared to healthy individuals. Rev. mex. oftalmol [online]. 2021, vol.95, n.2, pp.56-62. Epub June 25, 2021. ISSN 2604-1227. https://doi.org/10.24875/rmo.m20000143.
Purpose:
To describe the findings in central macular thickness, mean macular thickness, central choroidal thickness, and foveal avascular zone at the superficial and deep retinal plexus, and to compare the results with a group of healthy subjects.
Methods:
Descriptive study about SS-OCT and OCT-A findings in 28 eyes (14 patients) with electrophoretic confirmation of sickle cell disease and 60 eyes (30 patients) without systemic or ocular disorders.
Results:
In the sickle cell disease group, median central macular thickness was 194 vs. 229 mm in the healthy subjects group (p < 0.0001). The area of the foveal avascular zone at the superficial plexus showed a median value of 0.347 vs. 0.243 mm2 (p < 0.0001) and at the deep capillary plexus of 0.461 vs. 0.321 mm2 in the sickle cell disease and healthy subjects groups, respectively (p < 0.0001). The comparative measures of mean macular thickness and central choroidal thickness did not reveal significant statistical differences between groups.
Conclusions:
Compared to a healthy control group, patients with sickle cell disease had a statistically significant lower central macular thickness and an enlarged foveal avascular zone at both the superficial and deep plexuses. SS-OCT and OCT-A are non-invasive imaging modalities that provide high resolution images that can be useful to detect anatomic and micro vascular alterations in patients with sickle cell disease.
Keywords : Sickle cell disease; Optical coherence tomography angiography; Deep capillary plexus; Superficial capillary plexus; Swept source optical coherence tomography; Foveal avascular zone.