Abstract

CORTES-ESTEBAN, Patricia et al. High-grade serous epithelial ovarian cancer, BRCA negative, in two 18-year-old women: case report. Gac. mex. oncol. [online]. 2023, vol.22, suppl.1, pp.41-46.  Epub Sep 11, 2023. ISSN 2565-005X.  https://doi.org/10.24875/j.gamo.220000951.

Two previously healthy 18-year-old Mexican women referred for medical evaluation due to ascites. Clinical studies revealed the presence of ovarian-dependent tumors, and elevated CA-125. A diagnostic laparotomy was performed, with a pathology report of a high-grade papillary serous adenocarcinoma. BRCA 1 and 2 was performed and reported negative for both patients. Chemotherapy and antiangiogenic treatment were started. One of the patients was considered a candidate for a poly (ADP-ribose) polymerase inhibitor.

Keywords : Ovarian cancer; BRCA; PARP inhibitor.

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