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Gaceta mexicana de oncología
On-line version ISSN 2565-005XPrint version ISSN 1665-9201
Abstract
RODRIGUEZ-LOPEZ, Andrea G. et al. Evaluation of sialic acid concentrations and its association with the use of hormonal contraceptives. Gac. mex. oncol. [online]. 2022, vol.21, n.3, pp.89-98. Epub Oct 03, 2022. ISSN 2565-005X. https://doi.org/10.24875/j.gamo.22000081.
Objective:
To evaluate the relationship between the use of HC and the concentration of Sialic acid (CSA) detected in the saliva of 120 women from San Luís Potosí, Mexico.
Methods:
Three groups were evaluated control group, HC intake shorter than 4 years, and HC intake longer than 4 years. A questionnaire was applied, anthropometric measures were taken, and collection of saliva samples was carried out. The samples were analyzed with Raman-SERS, for which silver nanoparticles were synthesized, and the measurement of SA was held.
Results:
The concentrations were divided into three SA groups normal (≤ 4 mg/dL), risk (> 4-7 mg/dL), and altered(> 7 mg/dL). The maximum CSA was detected, which was 9.2 mg/dL. All the volunteers who used the intrauterine system (IUS) and most of the ones who used the pills and subdermal implant (SI) presented risk and altered concentrations.
Conclusions:
That there is an association between the HC and the CSA, presenting a higher concentration, those volunteers who used IUS, contraceptive pills, and SI.
Keywords : Breast cancer; Hormonal contraceptive; Sialic acid; SERS; Raman spectroscopy.