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Gaceta mexicana de oncología
On-line version ISSN 2565-005XPrint version ISSN 1665-9201
Abstract
KHOSRAVI-SHAHI, Parham; CABEZON-GUTIERREZ, Luis and CUSTODIO-CABELLO, Sara. Survival after maximum effort cytoreductive surgery and platinum-based chemotherapy in patients with epithelial ovarian cancer, fallopian tube carcinoma and primary peritoneal carcinomatosis: Experience of a Public University Hospital in Spain. Gac. mex. oncol. [online]. 2019, vol.18, n.1, pp.18-27. Epub Apr 25, 2022. ISSN 2565-005X. https://doi.org/10.24875/j.gamo.19000117.
Introduction:
Epithelial ovarian cancer (EOC), fallopian tube carcinoma (FTC) and primary peritoneal carcinomatosis (PPC) are associated with poor prognosis, and up to 15% of cases are hereditary. cytoreductive surgery (CRS) and platinum-based chemotherapy are the cornerstones of the treatment.
Material and methods:
We performed a retrospective study of a series of 43 consecutive cases using the Tumor Registry Database of our center, with the objective of determining progression-free survival (PFS) and overall survival (OS) in real life (primary end points); as well as post-progression survival (PPS) and the proportion of patients with germline mutations in genes related to hereditary EOC (secondary end points).
Results:
In our study, median PFS was 53 months, with a probability of PFS at 1, 3 and 5 years of 84, 54 and 40%, respectively. Median OS had not been reached, and the probability of OS at 1, 3 and 5 years was 89, 82 and 64%, respectively. Median PPS was 60 months, and the probability of 5-year PPS was 43%. A total of 7 patients (16.3%) had pathogenic germline mutations: three patients (6.9%) in the BRCA-2 gene; two (4.7%) in the BRCA-1 gene, one (2.3%) in the ATM gene and another in the MUTYH gene (2.3%).
Conclusions:
Our study demonstrates the importance of CRS and platinum-based chemotherapy in patients with EOC, FTC and PPC in the clinical practice; and highlights the relevance of genetic counseling in these patients.
Keywords : Debulking; PARP; Real world data; Prognosis.