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Revista médica del Hospital General de México
On-line version ISSN 2524-177XPrint version ISSN 0185-1063
Abstract
PADILLA-PEREZ, Javier et al. Fast kinetics of fundamental aortic contraction to phenylephrine compared to KCl only in male prepubertal and adult rats. Rev. med. Hosp. Gen. Méx. [online]. 2023, vol.86, n.3, pp.93-98. Epub Oct 16, 2023. ISSN 2524-177X. https://doi.org/10.24875/hgmx.22000087.
Background:
Phenylephrine (PHE) produces higher aortothoracic contractile tension with endothelium (T[ON]) compared to potassium chloride (KCl). Both are exponential triphasic responses (Φ1, Φ2, Φ3) but their kinetics have not been compared with the time constant (τ in s). Goal. To study the triphasic T[On] kinetics (τ: Φ1, Φ2(fundamental) and Φ3) of 1μM PHE vs 40mM KCl.
Material and methods:
We compared numerical values of τ1, τ2, τ3 of the T[On] of prepubertal male Wistar rats (without established reproductive capacity) with adult male ones.
Results:
Φ2 showed higher gain (g), shorter delay time (s), and faster kinetics of T[On] at PHE than at KCl.
Conclusions:
In the time course of T[On] only the fundamental exponential phase was faster with PHE than with KCl.
Keywords : Aorta; Tension; Kinetic; Exponential; Phenylephrine; KCl.
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