Services on Demand
Journal
Article
Spanish (pdf)
Article in xml format
Article references
Automatic translation
Send this article by e-mailIndicators
Cited by SciELO 
Access statistics
Related links
Similars in
SciELO
Share
Permalink
Revista alergia México
On-line version ISSN 2448-9190
Abstract
CORTES-GUZMAN, José Santiago; VELOZA, Karen T.; DOMINGUEZ, Juan D. and PINZON-TOVAR, Alejandro. Leukocytoclastic vasculitis as an adverse effect of propylthiouracil. A case report. Rev. alerg. Méx. [online]. 2023, vol.70, n.1, pp.51-54. Epub Aug 25, 2023. ISSN 2448-9190. https://doi.org/10.29262/ram.v70i1.1210.
Background:
The most common cause of hyperthyroidism is Graves' disease. Propylthiouracil (PTU) is one of the drugs used to treat this disease. Leukocytoclastic vasculitis is described among dermatologic adverse effects of PTU.
Case report:
A 18-year-old woman, allergic to methimazole, developed a vasculitis associated to ANCAs with characteristics of leukocytoclastic vasculitis, associated to PTU treatment. She did not present systemic involvement. PTU treatment was suspended. Two months later, the skin lesions had almost completely resolved.
Conclusions:
Leukocytoclastic vasculitis should be considered in the spectrum of complications caused by the consumption of propylthiouracil. The lesions can manifest over time, from a few weeks to years after taking the drug. When there is no systemic involvement, propylthiouracil suspension is sufficient to cure the disease.
Keywords : Hyperthyroidism; Graves disease; Propylthiouracil; Vasculitis associated with anti-neutrophil cytoplasm antibodies; Leukocytoclastic vasculitis.
