Abstract

VARGAS-RUIZ, D. E.; SERRANO-DIAZ, P. N.; HERNANDEZ-GOMEZ, G.  and  ACOSTA-TORRES, L. S.. Trends in periodontal regeneration with the use of nanoparticles: a systematic review of the literature. Mundo nano [online]. 2023, vol.16, n.30, e00069.  Epub Aug 14, 2023. ISSN 2448-5691.  https://doi.org/10.22201/ceiich.24485691e.2023.30.69696.

To carry out a systematic review of the literature to identify the types of nanoparticles and the effect they have on periodontal regeneration, a systematic review of the literature was carried out in the ScienceDirect, PubMed and SciELO databases. As inclusion criteria, the full-text original articles that included the use of nanoparticles (0-100 nm) for periodontal regeneration purposes published between 2016 and 2022 were taken into account. The search terms were “Periodontal regeneration AND nanoparticles AND dental materials”. 13 articles that met the inclusion and exclusion criteria were obtained and analyzed. nHA was found to have a high regenerative effect, followed by TiO2NPs, gold, calcium phosphate, chitosan, and iron oxide, among others. These NPs showed a periodontal regeneration effect for one to four weeks, mainly promoting osteoinduction, cytocompatibility, cell adherence, degradability, analgesia and biomineralization properties. Nanotechnology in the dental field is emerging as an attractive platform for advanced therapy in conjunction with dental biomaterials. In this review, it was found that nHA and TiO2NPs showed the best cellular response and in the shortest time to obtain regenerative results in periodontics in comparison to other NPs. There are still very few NPs analyzed for periodontal regeneration purposes, so their study is an emerging area. It is essential to recognize the possible limitations, consequences and adverse effects in short and long term, which must be studied in greater depth.

Keywords : nanotechnology; periodontal defects; nanohydroxyapatite; TiO₂NPs; osteoinduction; biocompatibility; biomineralization; bone regeneration.

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