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Cirugía y cirujanos
On-line version ISSN 2444-054XPrint version ISSN 0009-7411
Abstract
DEMIRKOL, Muhammed E. et al. C-reactive protein-to-lymphocyte ratio is a reliable marker in patients with COVID-19 infection: the CLEAR COVID study. Cir. cir. [online]. 2022, vol.90, n.5, pp.596-601. Epub Nov 18, 2022. ISSN 2444-054X. https://doi.org/10.24875/ciru.22000124.
Objective:
COVID-19 infection is characterized with elevation of inflammatory markers in bloodstream. A novel inflammatory marker, C-reactive protein (CRP)-to-lymphocyte ratio (CLR), is suggested to be associated with inflammation. We aimed to compare the CLR values of the deceased COVID-19 patients to the CLR of survived subjects.
Materials and Methods:
The patients with COVID-19 whom presented to outpatient or inpatient clinics of AbantIzzet Baysal University Hospital were enrolled to the present retrospective study. Subjects were grouped as either deceased or survived. CLR values of the groups were compared.
Results:
Study cohort was consisted of 568 subjects in deceased and 4753 patients in survived group. Median CLR of the deceased and survived groups were 90 (0.2-1679)% and 11 (0.2-1062)%, respectively (p < 0.001). The sensitivity (75%) and specificity (70%) of CLR (> 23.4% level) in detecting mortality were higher than those of CRP and ferritin (AUC 0.80, p < 0.001, 95% CI 0.78-0.82).
Conclusion:
We suggest that elevated CLR levels in COVID-19 patients on admission should alert physicians for poor outcome.
Keywords : COVID-19; Mortality; Inflammation; C-reactive protein-to-lymphocyte ratio.