Background:

Sepsis is an important cause of disease and death worldwide, and it has a complex and heterogeneous disease process. It is now recognized that biological markers improve sepsis classification and may facilitate the identification of different subclasses or endotypes of patients.

Objective:

To analyze the current concepts in translational biology that help to understand the heterogeneity in the response of the patient with sepsis.

Conclusions:

There are a number of biomarkers that could be useful for constructing endo-compound types that predict uncomplicated results in sepsis. These endotypes could help identify patients who deserve early antimicrobial onset or discontinuation.

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