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Revista mexicana de urología
On-line version ISSN 2007-4085Print version ISSN 0185-4542
Abstract
MONTANO-ROCA, Benjamín Enrique et al. Urologic manifestations of IgG4-related disease. Rev. mex. urol. [online]. 2020, vol.80, n.5, e06. Epub May 05, 2023. ISSN 2007-4085. https://doi.org/10.48193/revistamexicanadeurologa.v80i5.610.
IgG4-related disease (IgG4-RD) is a clinical entity characterized by elevated serum IgG4 and tumor-like inflammation, with tissue infiltration by IgG4 and plasma cells. IgG4-RD is rare, but clinically significant, and its urologic manifestations have been reported in the literature. The present review covers a broad spectrum, describing the pathologies related to the area of urology.
In 2003, Terumi Kamisawa was the first to recognize IgG4-RD, characterized by multiorgan lesions in patients with autoimmune pancreatitis and classified as an inflammatory and fibrotic entity with a dense lymphoplasmacytic infiltrate, positive for IgG4.1-3 It presents in middle-aged patients, between 59-68 years of age, with no clear distribution by sex, 4-6 and has different clinical presentations. The main urologic manifestations are inflammatory pseudotumors and lower urinary tract symptoms. The present article offers a clear, general overview of the disease, encompassing its pathophysiology, diagnosis, and treatment, from the perspective of urology.
Keywords : Pseudotumor; IgG4; Urology; Autoimmune.