Abstract

BORBOLLA SCHEGA, Itziar; LOPEZ ZERTUCHE, Daniel; DIAZ GREENE, Enrique Juan  and  RODRIGUEZ WEBER, Federico Leopoldo. Psoriasis and cardiovascular implications. Acta méd. Grupo Ángeles [online]. 2021, vol.19, n.2, pp.253-257.  Epub Nov 23, 2021. ISSN 1870-7203.  https://doi.org/10.35366/100450.

Psoriasis is an immune-mediated and systemic inflammatory disorder that affects the skin and various organs. Its exact etiology is unknown, although it has predisposing genetic and epigenetic markers, in addition to the fundamental role of the immune system in its progression. It has effect on different systems, therefore, the adipose tissue has been shown to suffer dysfunction leading to insulin resistance and therefore to the metabolic syndrome, development of atherosclerosis and increased cardiovascular risk. Inflammation is the main pathophysiological factor in atherosclerosis, therefore the association of IL-17 with endothelial dysfunction, cardiovascular diseases and psoriasis has been studied where there is probably a positive correlation, according to the available evidence. In patients with this illness, heart diseases are the first or second cause of mortality, so high that mortality worldwide is 46%. There are alterations in the different types of cholesterol, triglycerides, lipoproteins and Apo A1, which together with autoimmune inflammation develop atherosclerosis and increase cardiovascular risk, which is also promoted by oxidation-modified lipoproteins and oxidized low-density lipoproteins. Coronary artery atherosclerosis has been discovered to be an important risk component for ischemic heart disease, patients with psoriasis have been found to have a higher prevalence and severity in coronary heart disease.

Keywords : Psoriasis; cardiovascular risk; metabolic syndrome; coronary artery disease.

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