Abstract

ARIZA ANDRACA, Raúl; HALABE CHEREM, José  and  LIFSHITZ GUINZBERG, Alberto. Statin intolerance and myopathy. Acta méd. Grupo Ángeles [online]. 2020, vol.18, n.3, pp.290-295.  Epub May 31, 2022. ISSN 1870-7203.  https://doi.org/10.35366/95407.

Adverse events due to statin’s administration are mainly confined to the musculoskeletal system. The different manifestations include nocebo effects, myalgias, muscular atrophy, myositis, and rarely rhabdomyolisis. Several etiopathogenic mechanisms are involved, but, individual susceptibility and multiple morbility are of major importance. Now a days there are strategies for their prevention and treatment, and, in cases of true actual intolerance or serious adverse events, alternative mechanisms to reduce c-LDL are available. Statins are one of the most widely used drugs in modern medicine and as such, it is important to recognize their adverse events in order to prevent them and to make and early diagnosis and treatment.

Keywords : Statin myopathy; statin toxicity; lipid lowering adverse effects; drug-induced myopathy; statin intolerance.

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