Abstract

SHARIFI, Faezeh; JAHANGIRI, Mansour  and  EBRAHIMNEJAD, Pedram. A Novel Efficient MPEG-Chitosan/HA Biopolymer for Adsorption of the Anticancer SN-38 Liquid Dispersions: Kinetics, Thermodynamic and Ex-Vivo Release Evaluation. J. Mex. Chem. Soc [online]. 2021, vol.65, n.4, pp.516-534.  Epub Feb 28, 2022. ISSN 1870-249X.  https://doi.org/10.29356/jmcs.v65i4.1505.

Amongst several drug delivery schemes for perfect drug delivery comprise biocompatibility, selective aiming of cancer cells, low-cost, and safe process of nanoparticle preparation. In this work, a new mPEG-chitosan/HA biopolymer was prepared as adsorbent nanoparticles (mNPs) for an efficient drug delivery system. The mNPs was synthesized by conjugating poly (ethylene glycol) methyl ether (mPEG) to chitosan and prepared through ionic gelation between mPEG-chitosan and hyaluronic acid (HA). The prepared mNPs were used to adsorption/release of 7-ethyl-10-hydroxycamtothecin (SN-38) from its liquid dispersions. The mNPs adsorbent was characterized by Fourier transforms infrared spectroscopy (FT-IR), differential scanning calorimetry (DSC), scanning electron microscopy (SEM). The results demonstrated that the adsorption isotherm of SN-38 on mNPs follows Langmuir model, and the adsorption capacity was 346.511 mg g-1. Besides, the pseudo-first order kinetic well fitted the equilibrium data. Further, thermodynamic parameters including ΔH, ΔG and ΔS were calculated which demonstrated that the physical spontaneous adsorption was prevailing. In addition, the ex- vivo release of SN-38 from mNPs were in good agreement with Korsmeyer-Peppas equation indicating the drug release process was governed by diffusion phenomena. The above results revealed that mNPs containing SN-38 was a good candidate for the drug delivery systems.

Keywords : Nanoparticles; adsorption; kinetics; thermodynamics; ex-vivo release.

        · abstract in Spanish     · text in English     · English ( pdf )