Abstract

CRISOSTOMO-LUCAS, Carmela et al. Synthesis, Characterization and Cytotoxic Activity of Tioconazole Coordination Compounds with Nickel(II), Palladium(II) and Platinum(II). J. Mex. Chem. Soc [online]. 2018, vol.62, n.4, pp.225-237.  Epub July 02, 2020. ISSN 1870-249X.  https://doi.org/10.29356/jmcs.v62i4.563.

Coordination compounds of nickel(II), palladium(II) and platinum(II) with tioconazole (tcnz) were synthesized and characterized by infrared, UV-Vis-NIR, elemental analysis, molar conductivity, magnetic susceptibility, mass spectrometry, NMR spectroscopy and X-ray diffraction. Tioconazole presented a monodentate coordination mode, through the nitrogen atom of the imidazolic ring. The nickel(II) compounds stabilized octahedral geometries. For the [Ni(tcnz)2(NO3)2].H2O compound, the nitrate anion present a bidentate coordination mode, while for the dinuclear [Ni(tcnz)2(OAc)2]2 .3H2O compound, the acetate groups behave as bridging ligands. When different molar ratios of the corresponding nickel(II) halides were used on the reaction synthesis, three tcnz ligands in the [Ni(tcnz)3Br2(H2O)], or six in [Ni(tcnz)6]Cl2 and [Ni(tcnz)6]Br2, are coordinated to the nickel(II) atom. The palladium(II) and platinum(II) compounds, [Pd(tcnz)2Cl2], [Pt(tcnz)2Cl2].2H2O and [Pd(tcnz)2(OAc)2], presented a square planar geometry. The [Ni(tcnz)6]X2 (X- = Cl, Br) compounds stabilized 3D supramolecular arrangements through hydrogen bonding and (∙∙∙( stacking interactions, between benzene rings of neighboring molecules. The in vitro cytotoxic activity of the synthesized compounds was studied in four different human carcinoma cell lines: HCT-15 (colon), HeLa (cervix-uterine), MCF-7 (breast) and PC-3 (prostate).

Keywords : Tioconazole; coordination compounds; nickel(II); palladium(II); platinum(II); intermolecular interactions; cytotoxic activity.

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