Abstract

SETAMDIDEH, Davood. DOWEX(R)50WX4/H₂O: A Green System for a One-pot and Three-Component Synthesis of isoxazol-5(4H)-one Derivatives. J. Mex. Chem. Soc [online]. 2015, vol.59, n.3, pp.191-197. ISSN 1870-249X.

A one-pot and three-component synthesis of 3-methyl-4-arylmethyleneisoxazol-5(4H)-ones was developed in the presence of DOWEX(R)50WX4 as the catalyst. The products were obtained in high yields (93-96%) and short reaction times (30-60 min). The present method provides an easy and efficient approach for the synthesis of this class of compounds, because of its clean reaction profile and operational simplicity.

Keywords : DOWEX(R)50WX4; isoxazol-5(4H)-one; one-pot reaction; water; green chemistry.

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