Abstract

REHMAN, Sadia; IKRAM, Muhammad  and  SUBHAN, Fazle. Synthesis of New Dicoumarol Based Zinc Compounds and their Invitro Antimicrobial Studies. J. Mex. Chem. Soc [online]. 2015, vol.59, n.2, pp.137-142. ISSN 1870-249X.

The dicoumarol derivatives were reacted with Zn (II) salt yielding the complexes (1-10) where metal centre was seen to be coordinated with dicoumarols through hydroxyl and carbonyl sites of attachments. All the synthesized compounds were studied spectroscopically using ¹H, ¹³C{¹H}-NMR, infrared spectroscopic method, and analytically using ES^(+,-)-MS, elemental analyses and conductance studies. The combined NMR and mass spectral data suggested the attachment of two ligands to the zinc (II) centre. Hydroxyl site is deprotonated and take part in charge neutralization of metal center. The synthesized zinc based dicoumarol compounds were screened for antimicrobial activities against Gram negative bacteria Escherichia coli, Salmonella typhus, Agrobacterium tumefaciens, Erwinia carotovora, Pseudomonas aeruginosa, Klebsiella pneumoniae, Gram positive bacteria Staphylococcus aureus, Bacillus subtilis, Bacillus atrophaeus and fungal Strain Candida albicans. All the compounds shown exceptional antimicrobial and antifungal activities.

Keywords : Dicoumarols; zinc compounds; spectral analysis; antimicrobial; antifungal activities.

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