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Journal of the Mexican Chemical Society
Print version ISSN 1870-249X
Abstract
MALEKI, Behrooz and SEDIGH ASHRAFI, Samaneh. "In Situ" Generated "HCl": A Highly Efficient Catalyst for One-Pot Synthesis of 1H -Indazolo [1,2-b]phthalazine-1,6,11-triones and 1H- pyrazolo[1,2-b]phthalazine-5,10-diones under Solvent-Free Conditions. J. Mex. Chem. Soc [online]. 2014, vol.58, n.2, pp.159-167. ISSN 1870-249X.
The rapid and environmental synthetic route to produce 1H-indazolo[1,2-b] phthalazine-1,6,11-triones and 1H-pyrazolo[1,2-b]phthalazine-5,10-diones derivatives have been developed via multi-component and one-pot reactions of various aldehydes, cyclic or acyclic 1,3-diketones with: i) phthalhydrazide or ii) phthalic anhydride-hydrazinium hydroxide using wet 2,4,6-trichlorotriazine (TCT) as catalyst under solvent-free conditions. Simple and mild reaction conditions, the use of a cheap catalyst and easy workup and isolation are notable features of this method.
Keywords : 1H-Indazolo[1,2-b]phthalazine-1,6,11-triones; 1H-pyrazolo[1,2-b]phthalazine-5,10-diones; 2,4,6-trichlorotriazine; 1,3-diketones; phthalhydrazide; aldehydes; solvent-free reactions.