Abstract

BRAVO-GOMEZ, María Elena; HERNANDEZ DE LA PAZ, Ana Laura  and  GRACIA-MORA, Isabel. Antineoplastic Evaluation of Two Mixed Chelate Copper Complexes (Casiopeínas^®) in HCT-15 Xenograft Model. J. Mex. Chem. Soc [online]. 2013, vol.57, n.3, pp.205-211. ISSN 1870-249X.

Casiopeínas^® is a family of copper complexes with the general formulae [Cu(N-N)(N-O)]NO₃ and [Cu(N-N)(O-O)]NO₃; where N-N = substituted aromatic diimine (2,2'-bipyridine (bipy) or 1,10-phenanthroline (phen)); N-O = α-aminoacidate or a peptide; and O-O = acetylacetonate (acac) or salicylaldehydate. These compounds have shown antiproliferative activity in vitro and antitumor activity in several mouse models with promissory results. Efforts have been done in order to understand the role played by ligands in the biological activity. With the aim of finding out the effect of secondary ligand (N-O or O-O), two of the most active complexes in vitro assays were selected to perform in vivo study on HCT-15 colon adenocarcinoma xenograft model. Both complexes, [Cu(3,4,7,8-tetramethyl-1,10-phenanthroline)(glycinato)]NO₃ (1) and [Cu(3,4,7,8-tetramethyl-1,10-phenanthroline)(acetylacetonato)]NO₃ (2) share the same diimine ligand and the secondary ligand changes from glycinate (gly) to acac. Results show that 2 is effective to reduce tumor size but 1 does not achieve the values required according to protocols, revealing an important difference between compounds attributable to change of ligand from gly to acac.

Keywords : Copper; mixed chelate; anticancer compounds; xenograft models; SAR relationships.

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