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Journal of the Mexican Chemical Society

Print version ISSN 1870-249X


HERNANDEZ-CHAVEZ, Ignacio et al. Antigiardial Activity of Cupania dentata Bark and its Constituents. J. Mex. Chem. Soc [online]. 2012, vol.56, n.2, pp.105-108. ISSN 1870-249X.

The MeOH extract of Cupania dentata bark (Sapindaceae) as well as its hexane, CH2Cl2, EtOAc, and BuOH fractions showed high activity against Giardia lamblia trophozoites (IC50 = 2.12-9.52 μg/mL). The phytochemical study of fractions resulted in the isolation of taraxerone (1), taraxerol (2), scopoletin (3), and two mixtures of steroidal compounds. Taraxerone was the metabolite with the highest giardicidal activity (IC50 = 11.33 μg/mL).

Keywords : Cupania dentata; Sapindaceae; giardicidal activity; taraxerone; taraxerol; scopoletin; sterols.

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