Abstract

RIVERA ISLAS, Jesús  and  BUHSE, Thomas. Kinetic Modeling of Chiral Amplification and Enantioselectivity Reversal in Asymmetric Reactions. J. Mex. Chem. Soc [online]. 2007, vol.51, n.2, pp.117-121. ISSN 1870-249X.

Nonlinear effects in asymmetric synthesis and the occasionally observed reversal of the enantioselectivity of the employed catalyst are evaluated by a generalized kinetic approach. A non-autocatalytic and an autocatalytic reaction system are considered as two different prototype scenarios. It is predicted that during the course of enantioselectivity reversal in the non-autocatalytic system a gradual transition between both optically active states under loss of chiral amplification occurs while in the autocatalytic system a sharp transition under retention of chiral amplification is observed.

Keywords : Asymmetric synthesis; chiral amplification; nonlinear effects; organozinc additions; catalysis.

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