Abstract

BROON, Norberto J et al. Inflammatory response of Bioceramic material to dentin tube implantation in rats’ subcutaneous tissue. Rev. Odont. Mex [online]. 2016, vol.20, n.3, pp.174-178. ISSN 1870-199X.  https://doi.org/10.1016/j.rodmex.2016.08.004.

The aim of the present article was to assess inflammatory response caused by implantation of Bioceramic material in rats’ subcutaneous tissue. Nine male Wistar rats were used (Rattus Norvegicus) to which four dentin tubes filled with Bioceramic sealing cement material and one empty tube (control group) were implanted. Results were analyzed in three time periods (96 hours, 10 and 21 days). Animals were sacrificed by anesthetic overdose. Obtained samples were processed by hematoxylin and eosin staining in order to be analyzed with microscope. Results after 96 hours revealed moderate inflammation in 75% of all cases and severe inflammation in 25% of all cases. Ten days later, inflammation decreased from moderate (67%) to mild (25%). At the final period of 21 days, moderate to mild inflammation was observed (50%). It was concluded that there was presence of moderate to severe inflammation at initial periods which decreased to mild inflammation at the final period. «Bioceramic» brand material exhibits acceptable biological response in rats’ subcutaneous tissues.

Keywords : Bioceramic; inflammation; biocompatibility; mineral trioxide aggregate.

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