Abstract

BARRIOS DE TOMASI, Eliana  and  JUAREZ, Jorge. Naltrexone treatment decreases water intake without affecting alcohol consumption, and suppresses the binge eating after alimentary deprivation. Rev. mex. cienc. farm [online]. 2014, vol.45, n.1, pp.41-50. ISSN 1870-0195.

Present study assessed the effects of naltrexone on the patterns of food, alcohol and water consumption under free-feeding and food deprivation in rats. Wistar rats were treated with either naltrexone 10mg/Kg/day, s.c. or saline solution at 0.2mL/day, for 14 days. Under free-feeding condition, water consumption decreased between 2 and 4 h after the naltrexone injection. Under periodic food deprivation, naltrexone suppressed the binge for food following the feeding re-exposure; decreased water intake more extensively than in free-feeding condition, and did not affect alcohol consumption. Results suggest the participation of opioid activity in the regulatory mechanisms of liquid intake as a primary incentive as much in free-feeding as in food deprivation condition, and findings support that opioid system plays an important role in the appetitive mechanisms of feeding behavior, particularly during food-deprivation.

Keywords : Naltrexone; Food intake; Alcohol consumption; Water consumption; Food deprivation; Opioid receptor antagonist; Opioid system.

        · abstract in Spanish     · text in English     · English ( pdf )