Abstract

MARTINEZ, Hector R. et al. The underrated nervous system involvement by COVID-19. Rev. mex. neurocienc. [online]. 2020, vol.21, n.4, pp.158-162.  Epub Oct 25, 2021. ISSN 2604-6180.  https://doi.org/10.24875/rmn.20000037.

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a highly pathogenic virus that causes severe pneumonia and acute respiratory distress syndrome. On March 11, 2020, this novel coronavirus was declared a pandemic by the World Health Organization. To date, millions of patients have been infected. Recent reports indicate that a substantial proportion of cases present with neurological symptoms. However, it remains to be elucidated whether these manifestations are secondary to direct nervous system invasion, indirect damage mediated by a systemic inflammatory response, or a combination of both. In this review, we explore the potential routes for central nervous system involvement, the possible pathogenic mechanisms in the nervous system and the conceivable neurological long-term sequela of infection by SARS-CoV-2 infection. Future efforts should concentrate on clarifying the pathophysiology of the neurological component of COVID-19.

Keywords : COVID-19; SARS-CoV-2; Coronavirus; Neurological manifestations; Nervous system.

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