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Boletín médico del Hospital Infantil de México
Print version ISSN 1665-1146
Abstract
HERNANDEZ, Eduardo J.; TAPIA, Brenda D.; GUTIERREZ-AGUILAR, Ruth and FRIGOLET, María E.. Trans-palmitoleic acid does not modify the inflammasome expression in a rodent model of diet-induced obesity. Bol. Med. Hosp. Infant. Mex. [online]. 2023, vol.80, n.3, pp.211-216. Epub Sep 11, 2023. ISSN 1665-1146. https://doi.org/10.24875/bmhim.23000049.
Background:
Metabolic disorders such as obesity and type 2 diabetes (T2D) coincide with an increased expression of pro-inflammatory factors. The NLRP3 inflammasome is a complex that activates the pro-inflammatory cytokine IL-1β. (NOD-like receptor protein 3). Some nutrients, such as fatty acids, influence inflammatory processes. For example, in clinical studies, higher trans-palmitoyl acid (TP) concentrations coincide with lower adiposity and lower risk of developing T2D. This study aims to evaluate the effect of TP on NLRP3 expression in a rodent model of diet-induced obesity (DIO).
Methods:
C57BL/6J mice were fed ad libitum with a control or a high-fat diet (HFD), added with or without TP (3 g/kg diet), for 11 weeks. IL-1β was quantified in serum, and NLRP3-related gene expression was explored in epididymal adipose tissue.
Results:
Despite increased weight gain in both high-fat groups, the high-fat TP group gained less weight than the high-fat group. In addition, NLRP3 and caspase-1 expression was higher in the HFD groups, but no differences were observed between the HFD and the HFD TP groups. Serum IL-1β levels were not different among groups.
Conclusions:
Diet supplementation with TP prevents weight gain and has a neutral influence over NLRP3 expression and IL-1β concentration in a DIO mice model.
Keywords : Trans-palmitoleic acid; Inflammasome; NLRP3; Obesity; Type 2 diabetes.