Abstract

RIOS MORENO, Mildred Paola  and  PATINO GARCIA, Germán. Characteristics of idiopathic nephrotic syndrome at an unusual age in a tertiary-level pediatric hospital in Guadalajara, Jalisco, México. Bol. Med. Hosp. Infant. Mex. [online]. 2011, vol.68, n.4, pp.271-277. ISSN 1665-1146.

Background. Nephrotic syndrome (NS) is diagnosed by the presence of massive proteinuria, hypoalbuminemia, edema and hypercholesterolemia. The usual onset is between 2 and 10 years of age. This study was conducted to determine the features of idiopathic NS in patients at an unusual age. Methods. A retrospective study was carried out in the Nephrology Department at the Pediatrics Hospital, Centro Medico Nacional de Occidente, Guadalajara, Mexico from January 2007-June 2009. Twenty three cases were analyzed to evaluate clinical features, biochemical parameters and histopathological spectrum. Medical management and outcome were established. Results. We analyzed 10 patients <2 years of age and 13 patients >10 years of age. There were 11 females and 12 males. Mesangial proliferative glomerulonephritis was found in seven (30.4%) patients, diastolic hypertension in 16 (69.5%) patients, hematuria in 15 (65.2%) patients, and positive IgM immunofluorescence in renal biopsy in 13 (56.5%) patients. There were 13 patients who did not achieve remission (56.5%). Conclusions. There was no gender predominance in idiopathic NS patients with unusual age presentation. Mesangial proliferative glomerulonephritis was the most common histopathological subtype.

Keywords : nephrotic syndrome; infants; adolescents.

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