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Archivos de cardiología de México

On-line version ISSN 1665-1731Print version ISSN 1405-9940


CALDERON-COLMENERO, Juan; SANDOVAL ZARATE, Julio  and  BELTRAN GAMEZ, Miguel. Pulmonary hypertension associated with congenital heart disease and Eisenmenger syndrome. Arch. Cardiol. Méx. [online]. 2015, vol.85, n.1, pp.32-49. ISSN 1665-1731.

Pulmonary arterial hypertension is a common complication of congenital heart disease (CHD). Congenital cardiopathies are the most frequent congenital malformations. The prevalence in our country remains unknown, based on birthrate, it is calculated that 12,000 to 16,000 infants in our country have some cardiac malformation. In patients with an uncorrected left-to-right shunt, increased pulmonary pressure leads to vascular remodeling and endothelial dysfunction secondary to an imbalance in vasoactive mediators which promotes vasoconstriction, inflammation, thrombosis, cell proliferation, impaired apotosis and fibrosis. The progressive rise in pulmonary vascular resistance and increased pressures in the right heart provocated reversal of the shunt may arise with the development of Eisenmenger' syndrome the most advanced form de Pulmonary arterial hypertension associated with congenital heart disease. The prevalence of Pulmonary arterial hypertension associated with CHD has fallen in developed countries in recent years that is not yet achieved in developing countries therefore diagnosed late as lack of hospital infrastructure and human resources for the care of patients with CHD. With the development of targeted medical treatments for pulmonary arterial hypertension, the concept of a combined medical and interventional/surgical approach for patients with Pulmonary arterial hypertension associated with CHD is a reality. We need to know the pathophysiological factors involved as well as a careful evaluation to determine the best therapeutic strategy.

Keywords : Congenital heart disease; Pulmonary hypertension; Vasodilatador therapy; Eisenmenger syndrome; Mexico.

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