Abstract

RUIZ-FERNANDEZ, Nelina et al. Oxidized LDL and anti-oxidized LDL antibodies according uric acid levels in overweight women. Arch. Cardiol. Méx. [online]. 2011, vol.81, n.3, pp.188-196. ISSN 1665-1731.

Objective: To establish whether increased serum uric acid is associated with higher levels of oxidized LDL (oxLDL), antibodies against human oxidized LDL (oxLDL Ab) and ratios of LDL oxidation in overweight women. Methods: Cross-sectional study that included 114 women with body mass index > 25 kg/m2. We determined weight, height, waist circumference, blood pressure, glycemia, uric acid, lipid profile, creatinine, Apolipoprotein B (ApoB), oxLDL, oxLDL Ab, insulin and insulin resistance was estimated using HOMA. Body mass index, LDL-associated ApoB, rates of LDL oxidation and tertiles of uric acid were calculated. Metabolic syndrome was defined using NCEP/ATP III criteria. Results: Of the women studied 51.8% were overweight and the rest was classified as obese; 66.7% had metabolic syndrome. In the total group and overweight group, only the oxLDL/HDL cholesterol ratio was significantly higher in the last tertile of uric acid. The serum levels of circulanting oxLDL and oxLDL/cholesterol, oxLDL/HDL cholesterol, oxLDL/ApoB and oxLDL/ LDL-associated ApoB ratios were significantly higher among obese women located in the highest tertile of uric acid. Concentrations of oxLDL Ab and oxLDL/oxLDL Ab were not related to the uric acid. Serum uric acid and ApoB predicted the elevation of oxLDL. Conclusion: Increased serum uric acid was associated with more oxidation of LDL among obese women. This suggests the importance of regular monitoring of uric acid in overweight women. Prospective research should be conducted.

Keywords : Oxidized LDL; Antibodies against oxidized LDL; Uric acid; Obesity; Venezuela.

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