SciELO - Scientific Electronic Library Online

vol.76 issue2Viscum album aqueous extract induces inducible and endothelial nitric oxide synthases expression in isolated and perfused guinea pig heart: evidence of the coronary vasodilation mechanismHeart transplant in "Nuevo Leon" the first 33 cases author indexsubject indexsearch form
Home Pagealphabetic serial listing  

Services on Demand




Related links

  • Have no similar articlesSimilars in SciELO


Archivos de cardiología de México

On-line version ISSN 1665-1731Print version ISSN 1405-9940


LUPI HERRERA, Eulo; SANDOVAL ZARATE, Julio; CHUQUIURE VALENZUELA, Eduardo  and  CARRILLO, Arturo. The possible clinical role of the cardiac pulmonary power in patients with primary pulmonary hypertension: Initial observations. Arch. Cardiol. Méx. [online]. 2006, vol.76, n.2, pp.140-150. ISSN 1665-1731.

The heart is a muscular mechanical pump with an ability to generate both flow (cardiac output) and pressure in the systemic circulation as well in the pulmonary vascular bed. The product of flow output and systemic arterial pressure is the rate of useful work done, or cardiac power output (CP), therefore for the right ventricle and the pulmonary arterial vascular bed it will be: the product of flow output and mean pulmonary arterial pressure will be the rate of useful work done, or cardiac pulmonary power output (CPP). Cardiac pulmonary pumping reserve capability can be defined as the maximal cardiac pulmonary power output (CPP) achieved by the right heart during maximal stimulation. Therefore, CPP reserve is the increase in power output as the cardiac performance is increased from the resting to the maximally stimulated state. Recently, several studies have shown that CP is a direct indicator of overall cardiac function, as well is an indicator of exercise capacity and a powerful predictor of prognosis for patients with severe heart failure and ischemic cardiogenic shock. On this basis: 1. we decided to investigate the possible previously mentioned roles of the CP and CPP in patients with different degrees of pulmonary arterial hypertension (n = 137), but mainly in those with primary pulmonary arterial hypertension (PPH). PPH patients (n = 50), &as well as those with Eisenmenger's syndrome (n = 10) were found to have most abnormal resting CPP Indexes (I), (0.431 ±0.171, 0.607 ± 0.124 watts/m2, respectively). During exercise in PPH patients (n = 14), both CPI and CPPI reserves although they increase, were also found to be significantly diminished (CPI: from 0.546 ± 170 to 1,116 ± 0.275 watts/m2, p < 0.05), (CPPI: from 0.373 ± 0.156 to 0.837 ± 0.226 watts/m2, p < 0.05). 2. We also found, significant differences in resting CPPI between PPH responders and no responders patients to hydralazine (0.273 ± 0.04, 0.507 ± 0.142 watts/m2, respectively, p < 0.01). During exercise and under the influence of hydralazine, CPPI "reserve" was significantly diminished in those patients considered as not responders (0.507 ± 0.142 to 0.723 ± 0.232 watts/m2, p = ns) when compared with responders to the vasodilatorther-apy (0.273 ± 0.04 to 0.903 ± 0.057 watts/m2, p < 0.01 ). On the basis of these initial findings on CPPI in PPH patients, we think that the values of this parameter should be investigated as an index for classifying the severity of this arterial vascular disease, for selecting patients as responders or not to vasodilator therapy, and in the future, to explore the possibility of is usefulness as a prognostic predictor index of mortality in a large population of patients with PPH.

Keywords : Primary pulmonary hypertension; Cardiac pulmonary pow.

        · abstract in Spanish     · text in Spanish     · Spanish ( pdf )


Creative Commons License All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License