Abstract

ROSAS-HERNANDEZ, Alonso  and  MARTIN, Erika. Construcción de moléculas quirales: alquilación alílica asimétrica. TIP [online]. 2008, vol.11, n.2, pp.91-100. ISSN 1405-888X.

One of most powerful approaches for the formation of complex chiral molecules is the palladium-catalyzed asymmetric allylic alkylation. This reaction has been broadly studied with a great variety of substrates and nucleophiles under different reaction conditions and it has promoted the synthesis of new chiral ligands to be evaluated as asymmetric inductors. Although the mechanisms as well as the active species equilibria are known, the performance of the catalytic system depends on the fine tuning of factors such as: substrate type, nucleophile nature, reaction medium, catalytic precursor and ligand type.

Keywords : Allylic alkylation; asymmetric catalysis; chiral compounds; palladium.

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