Abstract

DOMINGUEZ-RAMIREZ, Lenin  and  GOMEZ-PUYOU, Marietta Tuena de. F₁F₀ ATP synthase: a proteic complex with a great functional and structural versatility. TIP [online]. 2005, vol.8, n.1, pp.18-27. ISSN 1405-888X.

In the primitive atmosphere, pyrophosphate could have been the energy carrier molecule that gave rise to ATP. During evolution, ATP substituted pyrophosphate because it showed a higher functional versatility. At the same time, the systems that carried out its synthesis or hydrolysis, such as the H+ pyrophosphatases, ATPases and mitocondrial ATP synthases showed a higher structural complexity and also diversified functionally by using a part of their structural components in order to perform functions different from those of ATP synthesis or hydrolysis. such findings have revolutionized the field of traditional bioenergetics and opened new pathways to the research of pathological and normal processes.

Keywords : ATP synthase; structure; function; ectopic localization.

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