Abstract

SANCHEZ-RECILLAS, A. et al. Spasmolytic and antibacterial effect of the Bursera graveolens (Kunth) species. Polibotánica [online]. 2020, n.49, pp.135-147.  Epub June 20, 2020. ISSN 1405-2768.  https://doi.org/10.18387/polibotanica.49.9.

Bursera graveolens Kunth is used in traditional Mayan medicine due to its antidiarrheal effect. This species has been poorly explored for pharmacological effects knowledge, and it lacks assays describing the antidiarrheal effect. Due to this lack of information, our teamwork conducted efforts to establish spasmolytic effect using rat isolated ileum and antibacterial effect using Escherichia coli, Salmonella enterica, Salmonella enteritidis and Salmonella choleraesuis. We evaluated three extracts (hexanic: HEBg, dichloromethanic: DEBg and methanolic: MEBg) of B. graveolens leaves. HEBg (Emax = 74.88%, EC50 = 97.38 µg/mL) and DEBg (Emax = 89.21%, EC50 = 87.15 µg/mL) extracts shown significant spasmolytic effect (*p<0.05) challenging papaverine, in spontaneous contraction of rat isolated ileum. HEBg shows antibacterial activity against four different bacteria’s, and was more efficient against E. coli, with a Minimal Inhibitory Concentration (MIC) asset in broth dilution equal to 5 mg/mL. The decrease in spontaneous contraction in the rat intestine as well as the antibacterial effect exerted on pathogenic enterobacteria demonstrated by the organic extracts of the leaves of B. graveolnes can be attributed to the presence of sesquiterpenes according to literature reports.

Keywords : Antibacterial activity; Bursera graveolens; diarrhea; rat ileum; ex vivo test.

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