Abstract

SIGLER, Luis et al. Heparin in a deep second degree burn in a murine model. Cir. gen [online]. 2011, vol.33, n.2, pp.86-90. ISSN 1405-0099.

Objective: To demonstrate the effects of heparin topically or intraperitoneally applied on the recovery from second degree burns in a murine model. Setting: Third level health care center Centro Médico Nacional ''20 de Noviembre'', ISSSTE. Design: Experimental study. Statistical analysis: t de Student. Material and methods: We studied three groups of five rats each in which a second-degree thermal burn was produced on their back, 10% of the body surface. The control group received 5 ml of saline solution on the burned area per day during 30 days; the second group received heparin and the third group received intraperitoneally applied heparin and saline solution applied topically on the burn. A biopsy of the burned area was obtained, alkaline phosphatase was determined, and photographs were taken at days 0, 15, and 30 after causing the burn. Biopsy demonstrated a similar dermal burn degree in the three groups. Results: When rats received heparin, either topically or peritoneally, they had a faster healing (50% faster) and with less scars than the control group. Level of alkaline phosphatase revealed a higher inflammatory response in the control group. All differences were significant at P < 0.05. Conclusions: Heparin, administered either in the peritoneum or topically in similar groups of rats with second degree burns, induced wound healing in half the time with less inflammation, and better epithelial recovery than treatment with saline solution without heparin

Keywords : Heparin; burns; wound healing; murine model.

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