Resumen

GALLARDO RIVERA, Raquel; ROJAS CRUZ, Araceli  y  VALERIO-ALFARO, Gerardo. Efecto del grupo protector en la especificidad de sustrato de la lipasa de Candida antarctica en la aminólisis de amino ésteres en disolvente orgánico. Rev. Soc. Quím. Méx [online]. 2004, vol.48, n.4, pp.300-304. ISSN 0583-7693.

A series of model amino esters containing different protective groups were tested to study the substrate specificity of the lipase from Candida antarctica fraction B lipase (CAL-B) to perform the synthesis of N-protected amino ester amides using n-butylamine as the nucleophilic agent in dioxane as solvent. The lipase showed a major preference toward substrates protected with the benzyloxycarbonyl group. An increase of reaction temperature from 28 to 40 °C increased reaction rate and yield of biocatalysed aminolysis.

Palabras llave : Amino esters; aminolysis; lipase; CAL-B; protective group.

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