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Revista de la Sociedad Química de México

Print version ISSN 0583-7693

Abstract

ESPINOSA, Miguel A.; TAMARIZ, Joaquín; PADILLA-MARTINEZ, Itzia I.  and  MARTINEZ-MARTINEZ, Francisco J.. Síntesis y estudio estructural por RMN de 1H y 13C de la N-[4-[2-(2-oxo-2H-1-benzopiranil-3-carboxamidil)etil]bencensulfonil]-N'-ciclohexilurea y de la N-[4-[2-(4-nitrobenzamidil)etil]-bencensulfonil]-N'-ciclohexilurea. Rev. Soc. Quím. Méx [online]. 2001, vol.45, n.4, pp.214-217. ISSN 0583-7693.

This contribution describes the synthesis and structural study in solution of the new sulfonylurea agents N-[4-[2-(2-oxo-2H-1-benzopyran-3-carboxamide)ethyl]-benzenesulfonyl]-N'-cyclohexylurea (5a) and N-[4-[2-(4-nitrobenzamide)ethyl]benzenesulfonyl]-N'-cyclohexylurea (5b). Full assignment of 1H and 13C NMR spectra in solution of the intermediates 1-4 was accomplished. The new compound 5a constitutes a member of an important class of sulfonylurea drug with potential pharmacological activity.

Keywords : Sulfonylurea drug; 13C and 1H NMR study.

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