Abstract

ARBID, Mahmoud S.; MAHMOUD, Sawsan S.  and  KORIEM, Khaled M. M. Study on the possible protective effect of melatonin and silymarin against the toxic effect of favism factor "Divicine". Rev. latinoam. quím [online]. 2010, vol.38, n.1, pp.12-20. ISSN 0370-5943.

Experiments were carried-out with Sprague Dawley rats to determine as the administration of Mt and Sy on the toxicity produced by DV, a free radical compound. IP injection of DV (250 mg/rat b.wt.) alone resulted in 100% mortality within 24 h accompanied by a rapid decrease in the concentration of GSH in RBCs. Administration of both doses of Mt (1 and 2 mg/kg) and Sy (22 mg/kg) with DV greatly reduced mortality and increased the concentration of GSH. Blood cells and hemoglobin also returned towards normal values. Liver enzymes (AST, ALT, ALP and bilirubin) and kidney function (urea and creatinine) were highly significant increased after divicine injection, while Mt and Sy in combination with DV returned these parameters to normal values.

Keywords : Divicine; GSH; melatonin; sylimarin; Favism; Rats.

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