Abstract

MARTINEZ-MEDINA, Manuel  and  LEON-GUTIERREZ, Marco Antonio. Comparison of serum value of C3 in survivors and non-survivors patients with septic shock. Rev. Asoc. Mex. Med. Crít. Ter. Intensiva [online]. 2015, vol.29, n.2, pp.99-104. ISSN 0187-8433.

Background: Elevated concentrations of C3a, has been found in patients with severe sepsis and septic shock. Objective: To investigate the value of C3 in survivors and non-survivors patients with diagnosis of septic shock and survival at 28 days. Material and methods: Prospective, longitudinal, observational and comparative study, we included 14 patients with septic shock. Results: 43% men and 57% women. Among survivors and non survivors patients the mortality for APACHE II was 40% in survivors and 55% non-survivors (p = 0.01), serum C3 was 69 mg/dL and 30 mg/dL in survivors and non-survivors respectively (p = 0.0001), lactate levels was 2 mmol/L and 4.1 mmol/L in survivors and non-survivors respectively (p = 0.03), finally the SvcO₂ was 72 and 65% in survivors and non-survivors patients respectively (p = 0.04). Lactate levels among patients with C3 greater than 30 mg/dL was 1.9 and 4.1 (p = 0.05), SvcO₂ was 74 and 56% (p = 0.03) among survivors and non-survivors respectively. All patients with C3 values less than 30 mg/dL died. Conclusions: There is a high consumption of C3 in patients with septic shock in both groups being much higher in the latter group. C3 levels less than 30 mg/dL are presented in non-survivors patients.

Keywords : Septic shock; C3; APACHE II; lactate; venous oxygen saturation (SvcO₂).

        · abstract in Spanish     · text in Spanish     · Spanish ( pdf )