Abstract

REYES CORCHO, Andrés et al. Tuberculosis and AIDS in Cuba: A study of two series of cases. Rev. Inst. Nal. Enf. Resp. Mex. [online]. 2006, vol.19, n.1, pp.16-27. ISSN 0187-7585.

Objective: Analysis of groups of patients with the acquired immunodeficiency syndrome (AIDS) and tuberculosis (TB) diagnosed before and after the use of highly active antiretroviral therapy (HAART) in Cuba. Methods: Chart analysis of 149 cases with AIDS and TB. Series I, 72 cases (January 1997-March 2001, before HAART). Series II, 77 cases (May 2001-June 2004, after HAART); all the patients were discharged from the "Instituto de Medicina Tropical 'Pedro Kourí" in Havana, Cuba. Results and conclusions: There was a predominance of young (30-33ys) males in both series; 58.3% and 57.1% of cases classified as AIDS at the appearance of TB; TB was the first indicator of AIDS in 64.9% of cases in Series II; 54.5% of cases in Series II and 36.4% in Series I had < 200 CD4 + TL cells, probably related to better immunologic status. Clinical profile was similar; fever of uknown origin, nocturnal sweats, dyspnea and regional lymphadenopathies were more frequent in Series II. Amongst TB cases, pulmonary disease was more frequent (79.2% and 75.3%, respectively); 9 cases (11.7%) of Series II had disseminated TB. Diffuse basal and mediastinal shadows and negative chest X rays were more frequent; there was no correlation between the counts of CD4+ TL cells and the clinical and radiological forms of TB. Series II had a lower invadence of positive sputum smears and positive cultures and a higher incidence of positive intradermal reaction to tuberculin and positive tissue diagnoses for TB.

Keywords : Acquired immunodeficiency syndrome; diagnosis; HIV infection; therapy, tuberculosis.

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