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Medicina interna de México

Print version ISSN 0186-4866


ALVAREZ-SAUCEDO, Roberto et al. Effect of the administration of vitamin K on the complications associated with end stage liver disease. Med. interna Méx. [online]. 2018, vol.34, n.4, pp.551-556. ISSN 0186-4866.


The administration of vitamin K are restricted to situations such as an antidote for vitamin K antagonists and hemorrhagic disease of the newborn, but due to its role in hemostasis, its use has been extended to other diseases, such as terminal chronic liver disease.


To identify the efficacy of adding vitamin K to the management of patients with terminal hepatic insufficiency with some state of decompensation.


A retrospective case-control study was done between 2016-2017 in patients with Child-Pugh C chronic liver disease during an episode of decompensation. Vitamin K (menadione sodium bisulfite) was administered at a dose of 10 mg intramuscular every 12 h for three days.


A total of 60 patients were studied, 30 received vitamin K, in the case of a hemorrhagic event, replacement therapy with fresh frozen plasma and cryoprecipitates were administered together. The mean age was 60 (25-86) years; all were male. Hemorrhage (85%) was the main cause of complication. Five cases (8.3%) died due to reactivation of the hemorrhage. The administration of vitamin K did not shorten the coagulation tests (TP, aPTT, INR) nor showed a mortality benefit. Only thrombosis such as encephalopathy showed an association on mortality.


The addition of vitamin K does not influence the complications in patients with terminal liver disease.

Keywords : Vitamin K; Chronic liver disease; Hepatic insufficiency; Hemorrhage.

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