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Revista de investigación clínica

On-line version ISSN 2564-8896Print version ISSN 0034-8376


GUTIERREZ-CASTRO, Macrina et al. Kikuchi-Fujimoto disease (histiocytic necrotizing lymphadenopathy) clinicopathologic and immunohistochemical study of 14 cases and its differential diagnosis with other reactive and neoplastic necrotizing lymphadenopathies. Rev. invest. clín. [online]. 2006, vol.58, n.5, pp.441-449. ISSN 2564-8896.

Kikuchi-Fujimoto disease also known as histiocytic necrotizing lymphadenopaty (HNL) is a rare entity, originally described in Japanese population, although currently it has been described all over the world. It is more frequent in young women and it is usually located in cervical lymph nodes. We report 14 cases of HNL in Mexican population, their clinicopathological and immunohistochemical study as well as a comparative study with other necrotizing lymphadenopaties due to B or T-cell lymphomas, tuberculosis, Epstein Barr virus infection, and non-specific necrosis. In our study we found that there was more expression of the immunomarkers CD68, MPO, CD123 and antikerat in OSCAR in the cases of HNL in contrast with the lesser or even null expression of the same markers in the necrotized lymph nodes of the comparative study group.

Keywords : Kikuchi-Fujimoto disease; Necrotizing lymphadenitis; Plasmocytoid dendrocytes; Citokeratin positive interstitial reticulum cells.

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