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Revista de investigación clínica

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NAMENDYS-SILVA, Silvio Antonio  and  POSADAS-CALLEJA, Juan Gabriel. Ventilator associated acute lung injury. Rev. invest. clín. [online]. 2005, vol.57, n.3, pp.473-480. ISSN 0034-8376.

Mechanical ventilation plays a central role In the critical care setting; but its use is closely related with some life threatening complications as nosocomial pneumonia and low cardiac performance. One of the most severe complications is called ventilator-associated lung injury (VALI) and it includes: Barotrauma, volutrauma, atelectrauma, biotrauma and oxygen-mediated toxic effects and it is related with an inflammatory response secondary to the stretching and recruitment process of alveoli within mechanical ventilation. The use of some protective ventilatory strategies has lowered the mortality rate 10% approximately.

Keywords : Ventilator-associated lung injury; PEEP; Low tidal volume; Protective ventilatory strategies.

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