Abstract

MANCILLA-URREA, Eduardo. The highly sensitized patient therapeutic alternatives for kidney transplantation. Rev. invest. clín. [online]. 2005, vol.57, n.2, pp.206-212. ISSN 2564-8896.

Patients become sensitized after exposure to non-self human leukocyte antigen (HLA) during pregnancy, blood transfusion, and organ transplantation. Performing transplantation in highly sensitized receptors represents a challenge for transplant programs, organ allocation organizations and usually patients are forced to stay on transplant waiting lists for many years and ultimately may never find a donor. There are various approaches that can be adopted in order to transplant these patients such as plasmapheresis, immunoadsorption, intravenous immune globulin, anti-timocitic agents, monoclonal antibodies (anti CD-20) and splenectomy with similar results as obtained in non highly sensitized patients with the increased risk of severe and recurrent rejection which may carry implications for long-term graft outcomes. Thus a positive crossmatch test is not necessarily an absolute contraindication and allows access for transplantation.

Keywords : Renal transplant; Highly sensitized patients.

        · abstract in Spanish     · text in Spanish     · Spanish ( pdf )