Abstract

CABRERA-SANCHEZ, Carlos Francisco; SANCHEZ-GODINEZ, J. Yureri  and  GONZALEZ, Yolanda. Repositioning drugs and specific drugs in preclinical phase for COVID-19. Neumol. cir. torax [online]. 2021, vol.80, n.4, pp.258-268.  Epub Sep 30, 2022. ISSN 0028-3746.  https://doi.org/10.35366/103451.

Drug repositioning is an activity commonly performed by laboratories, and consists of the commercial use of a drug for a different purpose for which it was investigated or approved. In 2009, the COVID-19 pandemic began, caused by a new virus, SARS-CoV-2, a virus for which the human population has no immunity, and for which there is no effective treatment. As a first strategy to treat severely ill patients, drugs were repositioned for emergency use if they were shown to be at least theoretically effective against SARS-CoV-2. Once the results of the clinical studies were available, their effectiveness in preventing severe and/or fatal cases was evaluated. If the drug showed significant effectiveness, the World Health Organization (WHO) issued a recommendation for its use, otherwise a warning was issued to discontinue its use for COVID-19. This review describes the drugs that have been repositioned following this process, as well as the new SARS-CoV-2 specific drugs that are in experimental and preclinical phases.

Keywords : Drug repositioning; emergency use; COVID-19; SARS-CoV-2.

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