Abstract

HERNANDEZ GOMEZ-CRESPO, Francisco; BARRERA-RODRIGUEZ, Raúl  and  CHAVARRIA-GARCES, Jorge. Cellular, physiological, and biochemical markers associated with acute lung injury (ALI/ARDS). Neumol. cir. torax [online]. 2015, vol.74, n.1, pp.36-49. ISSN 0028-3746.

ARDS is a clinical syndrome secondary to acute lung injury, which leads to damage of the alveolar pulmonary capillary membrane, with increased permeability. The clinical description of the syndrome has been discussed in several reviews; however, it's still difficult to predict the clinical behavior that patients will have, some of them decay rapidly while others quickly achieve their improvement. Knowledge of the molecular aspects that regulate physiological processes will be discussed in this review, in order to identify possible genetic markers, predictive value to identify patients who may be more susceptible to develop ARDS, or a patient group more likely to have a better response to a particular treatment and the prognosis of individual patients.

Keywords : Acute lung injury; respiratory distress syndrome; biomarkers; treatment outcome.

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