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Revista de la Facultad de Medicina (México)
On-line version ISSN 2448-4865Print version ISSN 0026-1742
Abstract
GUADARRAMA-ORTIZ, Parménides; REGALADO GUERRA, Ximena; CASTILLO-RANGEL, Carlos and ANGELES-CASTELLANOS, Manuel. Multiple sclerosis, neurological disease with high social impact: back to the old treatment. Rev. Fac. Med. (Méx.) [online]. 2014, vol.57, n.6, pp.5-10. ISSN 2448-4865.
Multiple sclerosis (MS) is a chronic inflammatory and immune-degenerative disease that affects young people and has a high social impact due to direct and indirect costs.
Objective:
Regulate neurodegenerative process through a suitable modulation of inflammatory factors by using methylprednisolone and evaluation with Magnetic Resonance studies.
Patients and methods:
Female patients between the 1st and 5th decade of life, with diagnosis of Multiple Sclerosis, were included in the study if they met the criteria of McDonal 2010 (specially space and time monitoring) methylprednisolone boluses were administered regularly, even when the patient had no relapses, and the patients were then evaluated with Magnetic Resonance per annum, with a follow-up of up to 15 years.
Results:
There is a marked decrease of lesion in function of time and the bolus administration of methylprednisolone, and lesions disappeared entirely after 3 to 10 years of administration.
Conclusions:
The regular bolus administration of methylprednisolone attenuates the inflammatory process and the damage to the blood brain barrier and thus contributes in preventing neurodegeneration and is coadyuvant in remyelination.
Keywords : Immune-inflammatory disease methylprednisolone; magnetic resonance; remyelination; neurodegeneration; neuroimagen.
